Silver ion dressing effects on healing of chronic wound

doi:10.3969/j.issn.2095-4344.2013.42.024

Abstract

Abstract:

BACKGROUND: Silver ion dressing can reduce tissue necrosis, accelerate the epithelial formation, relieve the patient’s pain during the treatment, and strengthen various growth factors for wound repair, which is based on the theory of wet healing theory. It has obvious advantages for chronic wound healing, such as anti-infection and promoting wound granulation and epithelial hyperplasia.
OBJECTIVE: To observe the efficacy of silver ion dressing used in healing of chronic wound.
METHODS: A total of 40 patients who had chronic wounds were selected from Tangshan Branch Hospital of
Nanjing General Hospital of Nanjing Military Command. All cases were divided into two groups. The treatment group was treated with silver ion dressing, and the control group was treated with routine dressing. Secretions extracted from wound were used for bacterial culture prior to and 7, 14, and 21 days after treatment. Healing condition and velocity were observed and wound pain was assessed using visual analog scale.
RESULTS AND CONCLUSION: The detection rate of wound bacteria in the treatment group was significantly lower than that of the control group (P < 0.05). And the time of healing was shorter in the treatment group than the control group (P < 0.05). Wound pain during dressing change was relieved (P < 0.05). Medical costs showed no difference between the two groups (P > 0.05). No adverse reaction occurred in the two groups. These findings indicate that silver ion dressing used in chronic wound healing can prevent infection and promote wound granulation or epithelial hyperplasia. It can effectively promote wound healing and has no bad reaction.

Key words: silver, wounds and injuries, biological dressings, wound healing

CLC Number:

R318

Liu Tao, Xu Hai-dong . Silver ion dressing effects on healing of chronic wound[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(42): 7494-7500.

Figures/Tables 7

References

[1] 葛小静,章宏伟,史京萍,等.藻酸盐银联合水凝胶敷料对慢性创面愈合的作用[J]. 中国组织工程研究,2012,16(3):539-524.
[2] Elsner JJ,Berdicevsky I,Zilberman M.In vitro microbial inhibition and cellular response to novel biodegradable composite wound dressings with controlled release of antibiotics.Acta Biomater.2011;7(1):325-336.
[3] Zajicek R,Matouskova E,Broz L,et al. New biological temporary skin cover Xe-Derma(®) in the treatment of superficial scald burns in children. Burns.2011;37(2): 333-337.
[4] 丁华荣,张宪发,梁自乾,等.纳米银与磺胺嘧啶银治疗烧伤创面疗效比较的Meta分析[J].中国组织工程研究,2012,16(16): 2967-2970.
[5] 李晓普,黄跃生,彭毅志,等. 纳米晶体银敷料治疗烧伤后残余创面的多中心临床研究[J].中华烧伤杂志,2006,22(1):15-18.
[6] Gristock R.Silver dressings:the need for clarity.J Wound Care. 2005;14(1):30.
[7] Dowsett C.The use of silver-based dressings in wound care.Nurs Stand.2004;19(7):56-60.
[8] Thomas S,Ashman P.In-vitro testing of silver-containing dressings.J Wound Care.2004;13(9):392-393.
[9] Thomas S,McCubbin P.A comparison of the antimicrobial effects of four silver-containing dressings on three organisms.J Wound Care.2003;12(3):101-107.
[10] Slezak A,Kucharzewski M,Grzegorczyn S,et al. Study of transport properties of the polymeric membranous dressing with silver ions.Polim Med.2005;35(4):3-11.
[11] 李民,刘亚明,林倩君,等.纳米银敷料对烧伤创面保护作用的观察[J].中国医师进修杂志,2006,20(5):11-13.
[12] 陈炯,韩春茂,林小玮,等.纳米银敷料在修复Ⅱ度烧伤创面的应用研究[J].中华外科杂志,2006,44(1):50-52.
[13] Ziegler K,Görl R,Effing J,et al.Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds[.Skin Pharmacol Physiol.2006;19(3):140-146.
[14] Lansdown AB,Williams A,Chandler S,et al.Silver absorption and antibacterial efficacy of silver dressings.J Wound Care. 2005; 14(4):155-160.
[15] Luo G,Tang J,He W,et al.Antibacterial effect of dressings containing multivalent silver ion carried by zirconium phosphate on experimental rat burn wounds.Wound Repair Regen.2008;16(6):800-804.
[16] Li J,Yan W,Jing L,et al.Addition of an alginate to a modified zeolite improves hemostatic performance in a swine model of lethal groin injury. J Trauma.2009;66(3):612-620.
[17] Percival SL,Thomas JG,Slone W,et al.The efficacy of silver dressings and antibiotics on MRSA and MSSA isolated from burn patients.Wound Repair Regen. 2011;19(6):767-774.
[18] Wilkinson LJ,White RJ,Chipman JK.et al.Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety.J Wound Care. 2011;20(11):543-549.
[19] Percival SL,Thomas J,Linton S,et al.The antimicrobial efficacy of silver on antibiotic-resistant bacteria isolated from burn wounds. Int Wound J.2012;9(5):488-493.
[20] Belcaro G,Cesarone MR,Errichi BM,et al.Silver oxide ointment wound dressing in venous ulcerations: home, self-management.Panminerva Med. 2011;53(3 Suppl 1): 29-33.
[21] Chen JP,Chiang Y.Bioactive electrospun silver nanoparticles-containing polyurethane nanofibers as wound dressings.J Nanosci Nanotechnol.2010; 10(11):7560-7564.
[22] Blanco Blanco J,Ballesté Torralba J. Local control treatment of bacteria found present in an infected bed sore by means of a hydropolymer dressingwith ionic silver.Rev Enferm.2009; 32(10):7-14.
[23] 刘仁海,高霞.含银离子敷料治疗2-3级糖尿病足溃疡42例[J].中国药业,2012,21(9):50-51.
[24] 傅开兰,谢幸华. 爱康肤~(TM)银抗菌敷料对慢性感染性创面愈合效果的影响[J].佛山科学技术学院学报:自然科学版,2010, 28(4):79-82.
[25] Hinman CD,Maibach H. Effect of air exposure and occlusion on experimental human skin wounds.Nature.1963;200: 377-378.
[26] 陶岚.爱康肤银抗菌敷料加速感染切口愈合效果的对照研究[J].中华现代护理杂志,2011,28(4):1766-1769.
[27] Kohr R.Moist healing versus wet-to-dry.Can Nurse.2001; 97(1): 17-19.
[28] Driver VR.Silver dressings in clinical practice.Ostomy Wound Manage. 2004;50(9A Suppl):11S-15S.
[29] Bin Ahmad M,Lim JJ,Shameli K,et al.Antibacterial activity of silver bionanocomposites synthesized by chemical reduction route[J]. Chem Cent J.2012;6(1):101.
[30] Saxena V,Hwang CW,Huang S,et al.Vacuum-assisted closure: microdeformations of wounds and cell proliferation.Plast Reconstr Surg. 2004;114(5):1086-1096。
[31] 苏天兰,时利群,李伟人,等.银离子敷料在感染伤口的应用效果观察[J].贵阳医学院学报,2010,35(4):390-391.
[32] Coban YK,Erbatur S,Aytekin AH. A useful combination in the treatment of toxic epidermal necrolysis: Octenoidine dihydrocholoride solution and Aquacel-Ag.Burns.2011; 37(3): 545-546.
[33] Lee JH,Chae JD,Kim DG,et al.Comparison of the efficacies of silver-containing dressing materials for treating a full-thickness rodent wound infected by methicillin-resistant Staphylococcus aureus. Korean J Lab Med.2010;30(1):20-27.
[34] Vogt PM,Andree C,Breuing K,et al. Dry, moist, and wet skin wound repair. Ann Plast Surg. 1995;34(5):493-499.
[35] Field FK,Kerstein MD.Overview of wound healing in a moist environment. Am J Surg.1994;167(1A):2S-6S.
[36] 朱守林.湿性疗法在慢性伤口处理中的应用观察[J].实用临床医药杂志,2010,14(6):67-69.
[37] Bergin E,Savage C.Surviving multiple obligations through stimulation, autonomy, and variation.J Health Organ Manag. 2011;25(4):455-468.
[38] Poli-de-Figueiredo LF,Garrido AG,Nakagawa N,et al.Experimental models of sepsis and their clinical relevance. Shock.2008;30 Suppl 1:53-59.
[39] Berman DW,Crump KS.A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type.Crit Rev Toxicol.2008;38 Suppl 1:49-73.
[40] 陈炯,韩春茂.Ⅱ度烧伤创面外用药的药物经济学评价[J].中华烧伤杂志, 2006,22(5):377-378.
[41] Guest JF,Taylor RR,Vowden K,et al.Relative cost-effectiveness of a skin protectant in managing venous leg ulcers in the UK.J Wound Care. 2012;21(8):389-394, 396-398.
[42] Foglia E,Restelli U,Napoletano AM,et al.Pressure ulcers management: an economic evaluation.J Prev Med Hyg. 2012;53(1):30-36.
[43] Fulton JA,Blasiole KN,Cottingham T,et al.Wound dressing absorption: a comparative study.Adv Skin Wound Care.2012; 25(7):315-320.
[44] Hankin CS,Knispel J,Lopes M,et al.Clinical and cost efficacy of advanced wound care matrices for venous ulcers.J Manag Care Pharm.2012;18(5):375-384.
[45] 王清华,钟文非,何萌.藻酸盐敷料的临床应用：与传统材料的特征的比较[J].中国组织工程研究与临床康复,2010,14(3): 533-536.
[46] 黄国宝,张磊,张科验,等.海藻盐敷料应用于难愈性烧伤创面的随机对照[J].中国组织工程研究与临床康复,2010,14(34): 6355-6358.
[47] 李晓琴,但卫华,王康建,等.体表创面修复材料的研究进展[J].材料导报,2009,23(1):374-377.
[48] Manizate F,Fuller A,Gendics C,et al.A prospective, single-center, nonblinded, comparative, postmarket clinical evaluation of a bovine-derived collagen with ionic silver dressing versus a carboxymethylcellulose and ionic silver dressing for the reduction of bioburden in variable-etiology, bilateral lower-extremity wounds. Adv Skin Wound Care. 2012;25(5):220-225.
[49] Cox SG,Cullingworth L,Rode H.Treatment of paediatric burns with a nanocrystalline silver dressing compared with standard wound care in a burns unit: a cost analysis.S Afr Med J. 2011;101(10):728-731.
[50] Qin Y.Silver-containing alginate fibres and dressings.Int Wound J. 2005;2(2):172-176.